Atherosclerosis and Matrix Metalloproteinases: Experimental Molecular MR Imaging in Vivo
نویسندگان
چکیده
منابع مشابه
Aliskiren Inhibits Neointimal Matrix Metalloproteinases in Experimental Atherosclerosis.
BACKGROUND The renin-angiotensin system (RAS) plays an important role in atherosclerosis. Acting via the angiotensin II receptor, type 1, oxidative stress increases and contributes to endothelial dysfunction and vascular inflammation. Renin exerts effects through a renin receptor causing an increase in the efficiency of angiotensinogen cleavage and facilitates angiotensin II (Ang II) generation...
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BACKGROUND Matrix metalloproteinase (MMP) activation plays a key role in vascular remodeling. RP782 is a novel indium (111)In-labeled tracer with specificity for activated MMPs. We hypothesized that RP782 can detect injury-induced vascular remodeling in vivo. METHODS AND RESULTS Left common carotid artery injury was induced with a guidewire in apolipoprotein E(-/-) mice. Sham surgery was perf...
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Atherosclerosis continues to cause considerable morbidity and mortality in the Western countries. In response to cardiovascular risk factors, a cascade of compensatory structural events occurs within the vessel wall. It has become increasingly evident that significant alterations in the structure and composition of the extracellular matrix (ECM) play a key role in the atherogenic process. Far f...
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M atrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases, which are highly activated by inflammatory signaling, including that of angiotensin II (Ang II; Figure). Activated MMPs are able to degrade col-lagen, elastin, and other extracellular molecules, 2 probably resulting in aging, hypertension, and atherosclerotic effects within the arterial wall (for reviews). The modi...
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OBJECTIVE Despite great advances in our knowledge, atherosclerosis continues to kill more people than any other disease in the Western world. This is because our means of identifying truly vulnerable patients is limited. Prediction of atherosclerotic plaque rupture may be addressed by MRI of activated matrix metalloproteinases (MMPs), a family of enzymes that have been implicated in the vulnera...
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ژورنال
عنوان ژورنال: Radiology
سال: 2009
ISSN: 0033-8419,1527-1315
DOI: 10.1148/radiol.2511080539